Buparlisib hydrochloride

Also known as: NVP-BKM120 (Hydrochloride), NVP-BKM120 hydrochloride, BKM120 hydrochloride, BKM-120 hydrochloride, BKM 120 hydrochloride, BKM 120AAA, BKM120-AAA, Buparlisib HCl, 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine hydrochloride, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1), 5-(2,6-DiMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine hydrochloride, 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1)

Buparlisib hydrochloride (CAS 1312445-63-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C18H22ClF3N6O2 and a molecular weight of 446.854 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1312445-63-8
Jingsj CID: J-1986644-5
Molecular Formula: C₁₈H₂₂ClF₃N₆O₂
Molecular Weight: 446.854 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	446.144501
PSA	90.36000
LogP	2.67490
Storage Conditions	2-8℃

Activity & Biological Data

Target	p110α:52 nM (IC50) p110α-H1047R:58 nM (IC50) p110α-E545K:99 nM (IC50) p110δ:116 nM (IC50) p110β:166 nM (IC50) p110γ:262 nM (IC50) Vps34:2.4 μM (IC50) mTOR:4.6 μM (IC50)
Additional Information	[1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. [2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706.

Target

p110α:52 nM (IC50) p110α-H1047R:58 nM (IC50) p110α-E545K:99 nM (IC50) p110δ:116 nM (IC50) p110β:166 nM (IC50) p110γ:262 nM (IC50) Vps34:2.4 μM (IC50) mTOR:4.6 μM (IC50)

Additional Information

[1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. [2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706.

Frequently Asked Questions

What is the CAS number of Buparlisib hydrochloride?

The CAS number of Buparlisib hydrochloride is 1312445-63-8.

What are the molecular formula and molecular weight of Buparlisib hydrochloride?

Buparlisib hydrochloride has molecular formula C18H22ClF3N6O2 and molecular weight 446.854 g/mol.

What are the upstream and downstream products of Buparlisib hydrochloride?

For Buparlisib hydrochloride, Upstream Products: 4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine, 2-Amino-4-(trifluoromethyl)pyridine, 5-Bromo-4-(trifluoromethyl)pyridin-2-amine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Buparlisib hydrochloride (CAS 1312445-63-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986644-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.