O-Desmethyl gefitinib

Also known as: 4-(3'-chloro-4'-fluoroanilino)-7-hydroxy-6-(3-morpholinopropoxy)quinazoline, 4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-7-one, 4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol, 7-Quinazolinol, 4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-, Gefitinib Impurity 1, Gefitinib Impurity 13, Gefitinib O-Desmethyl Impurity, Gefitinib impurity H, M523595, O-Demethyl-Gefitinib, O-Desmethyl Gefitinib, O-DesmethylGefitinibmetabolite

O-Desmethyl gefitinib (CAS 847949-49-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C21H22ClFN4O3 and a molecular weight of 432.87600 g/mol. Key properties include a melting point of 117-120ºC, a boiling point of 606.4ºC at 760 mmHg, a density of 1.386g/cm3 and a flash point of 320.5ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 847949-49-9
Jingsj CID: J-1986190-6
Molecular Formula: C₂₁H₂₂ClFN₄O₃
Molecular Weight: 432.87600 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	117-120ºC
Boiling Point	606.4ºC at 760 mmHg
Density	1.386g/cm3
Flash Point	320.5ºC
Exact Mass	432.13600
PSA	79.74000
LogP	3.98350
Refractive Index	1.65

Activity & Biological Data

Target	IC50: 36 nM (EGFR)[2]
Additional Information	[1]. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57. [2]. McKillop D, et al. Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica. 2006 Jan;36(1):29-39.

Target

IC50: 36 nM (EGFR)[2]

Additional Information

[1]. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57. [2]. McKillop D, et al. Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica. 2006 Jan;36(1):29-39.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of O-Desmethyl gefitinib?

The CAS number of O-Desmethyl gefitinib is 847949-49-9.

What are the molecular formula and molecular weight of O-Desmethyl gefitinib?

O-Desmethyl gefitinib has molecular formula C21H22ClFN4O3 and molecular weight 432.87600 g/mol.

What are the upstream and downstream products of O-Desmethyl gefitinib?

For O-Desmethyl gefitinib, Upstream Products: Gefitinib, 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one, 4-(3-Chloropropyl)morpholine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "O-Desmethyl gefitinib (CAS 847949-49-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986190-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.