4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile

Also known as: Gefitinib impurity 1, 2-Nitro-4-methoxy-5-(3-morpholinopropoxy)benzonitrile, 4-Methoxy-2-nitro-5-(3-morpholinopropoxy)benzonitrile, 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile, 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile, Benzonitrile, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-, Gefitinib HCL InterMediates G4, Gefitinib PI-1

4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile (CAS 675126-26-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C15H19N3O5 and a molecular weight of 321.328 g/mol. Key properties include a boiling point of 522.3±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 269.7±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 675126-26-8
Jingsj CID: J-1974043-3
Molecular Formula: C₁₅H₁₉N₃O₅
Molecular Weight: 321.328 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	522.3±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	269.7±30.1 °C
Exact Mass	321.132477
PSA	100.54000
LogP	1.50
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.570

Activity & Biological Data

Additional Information	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Frequently Asked Questions

What is the CAS number of 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile?

The CAS number of 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile is 675126-26-8.

What are the molecular formula and molecular weight of 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile?

4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile has molecular formula C15H19N3O5 and molecular weight 321.328 g/mol.

What are the upstream and downstream products of 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile?

For 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile, Upstream Products: 4-methoxy-3-(3-morpholinopropoxy)benzonitrile, 4-(3-Chloropropyl)morpholine, Isovanillin; Downstream Products: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzamide, O-Desmethyl gefitinib, 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile (CAS 675126-26-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974043-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.