![Molecular structure of 1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 172889-26-8)](/images/chem_structures_svg/491/172889-26-8.svg)
1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Also known as: PP1, EI 275, AGL 1872, 4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine, 1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1-tert-Butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, PP 1 (enzyme inhibitor), CS-716
1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 172889-26-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C16H19N5 and a molecular weight of 281.356 g/mol. Key properties include a melting point of 205-207ºC, a boiling point of 478.8±40.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 243.4±27.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 172889-26-8
- Jingsj CID
- J-1985798-7
- Molecular Formula
- C16H19N5
- Molecular Weight
- 281.356 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 205-207ºC |
|---|---|
| Boiling Point | 478.8±40.0 °C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 243.4±27.3 °C |
| Exact Mass | 281.164032 |
| PSA | 69.62000 |
| LogP | 3.11 |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| Refractive Index | 1.652 |
| Storage Conditions | Desiccate at +4°C |
| Additional Property | DMSO: >20mg/mL |
GHS Safety & Compliance
- H301 — Toxic if swallowed
Activity & Biological Data
| Target | IC50: 5 nM (Lck), 6 nM (Fyn), 250 nM (EGFR), >50 μM (JAK2)[1] |
|---|---|
| Additional Information | [1]. Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 1996 Jan 12;271(2):695-701. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of 1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine?
The CAS number of 1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is 172889-26-8.
What are the molecular formula and molecular weight of 1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine?
1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine has molecular formula C16H19N5 and molecular weight 281.356 g/mol.
Is 1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hazardous?
1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "1-tert-Butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 172889-26-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1985798-7 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.