Nebivolol

Also known as: rac-Nebivolol, (RS)-1-((RS)-6-fluorochroman-2-yl)-2-(((RS)-2-((SR)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol, 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol), 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol], 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino]ethanol, 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol, R-65824, Nibivolol

Nebivolol (CAS 99200-09-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H25F2NO4 and a molecular weight of 405.43500 g/mol. Key properties include a melting point of 155-156°C(lit.), a boiling point of 600.5ºC at 760 mmHg, a density of 1.309 g/cm3 and a flash point of 316.9ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 99200-09-6
Jingsj CID: J-1985182-2
Molecular Formula: C₂₂H₂₅F₂NO₄
Molecular Weight: 405.43500 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	155-156°C(lit.)
Boiling Point	600.5ºC at 760 mmHg
Density	1.309 g/cm3
Flash Point	316.9ºC
Exact Mass	405.17500
PSA	70.95000
LogP	2.75450
Refractive Index	1.58
Storage Conditions	20°C

Activity & Biological Data

Target	IC50: 0.8 nM (β1-adrenergic receptor)[1]
Additional Information	[1]. do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21(3):224-235. [2]. Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71. [3]. Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48(4):677-84.

Target

IC50: 0.8 nM (β1-adrenergic receptor)[1]

Additional Information

[1]. do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21(3):224-235. [2]. Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71. [3]. Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48(4):677-84.

Frequently Asked Questions

What is the CAS number of Nebivolol?

The CAS number of Nebivolol is 99200-09-6.

What are the molecular formula and molecular weight of Nebivolol?

Nebivolol has molecular formula C22H25F2NO4 and molecular weight 405.43500 g/mol.

What are the upstream and downstream products of Nebivolol?

For Nebivolol, Upstream Products: 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran, Dibenzylamine, Benzylamine; Downstream Products: Diphenylpyraline hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nebivolol (CAS 99200-09-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1985182-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.