Pelitinib

Also known as: EKB-569, WAY-EKB 569, WAY 172569, WAY-172569, (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide, Pelitinib (EKB-569)

Pelitinib (CAS 257933-82-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H23ClFN5O2 and a molecular weight of 467.923 g/mol. Key properties include a melting point of 173-178ºC, a boiling point of 655.5±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 350.2±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 257933-82-7
Jingsj CID: J-1980173-1
Molecular Formula: C₂₄H₂₃ClFN₅O₂
Molecular Weight: 467.923 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	173-178ºC
Boiling Point	655.5±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	350.2±31.5 °C
Exact Mass	467.152435
PSA	90.28000
LogP	5.95
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.645
Storage Conditions	-20°C Freezer
Additional Property	DMSO: soluble5mg/mL, clear (warmed)

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	EGFR:38.5 nM (IC50)
Additional Information	[1]. Torrance CJ, et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med. 2000 Sep;6(9):1024-8. [2]. Nunes M, et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes. Mol Cancer Ther. 2004 Jan;3(1):21-7.

Target

EGFR:38.5 nM (IC50)

Additional Information

[1]. Torrance CJ, et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med. 2000 Sep;6(9):1024-8. [2]. Nunes M, et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes. Mol Cancer Ther. 2004 Jan;3(1):21-7.

Frequently Asked Questions

What is the CAS number of Pelitinib?

The CAS number of Pelitinib is 257933-82-7.

What are the molecular formula and molecular weight of Pelitinib?

Pelitinib has molecular formula C24H23ClFN5O2 and molecular weight 467.923 g/mol.

Is Pelitinib hazardous?

Pelitinib has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Pelitinib?

For Pelitinib, Upstream Products: Dimethylamine, 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile, 3-Chloro-4-fluoroaniline.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pelitinib (CAS 257933-82-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980173-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.