Masitinib

Also known as: AB1010, Masivet, Kinavet, 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide, 4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide, Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-

Masitinib (CAS 790299-79-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H30N6OS and a molecular weight of 498.642 g/mol. Key properties include a melting point of 90-95ºC and a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 790299-79-5
Jingsj CID: J-1980004-5
Molecular Formula: C₂₈H₃₀N₆OS
Molecular Weight: 498.642 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	90-95ºC
Density	1.3±0.1 g/cm3
Exact Mass	498.220184
PSA	101.63000
LogP	2.88
Refractive Index	1.682
Storage Conditions	Refrigerator

Activity & Biological Data

Target	IC50: 200 nM (Kit), 540 nM (PDGFRα), 800 nM (PDGFRβ)
Additional Information	[1]. Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258. [2]. Lawrence J, et al. Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells. Vet Comp Oncol, 2011, doi: 10.1111/j.1476-5829.2011.00291.x. [3]. Hahn KA, et al. Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309. [4]. Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010 Mar 4;5(3):e9430

Target

IC50: 200 nM (Kit), 540 nM (PDGFRα), 800 nM (PDGFRβ)

Additional Information

[1]. Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258. [2]. Lawrence J, et al. Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells. Vet Comp Oncol, 2011, doi: 10.1111/j.1476-5829.2011.00291.x. [3]. Hahn KA, et al. Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309. [4]. Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010 Mar 4;5(3):e9430

Frequently Asked Questions

What is the CAS number of Masitinib?

The CAS number of Masitinib is 790299-79-5.

What are the molecular formula and molecular weight of Masitinib?

Masitinib has molecular formula C28H30N6OS and molecular weight 498.642 g/mol.

What are the upstream and downstream products of Masitinib?

For Masitinib, Upstream Products: 4-Methyl-N3-[4-(3-pyridinyl)-2-thiazolyl]-1,3-benzenediamine, methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate, 4-[(4-methylpiperazin-1-yl)methyl]benzoyl chloride; Downstream Products: Masitinib mesylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Masitinib (CAS 790299-79-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980004-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.