Rotigotine hydrochloride

Also known as: (S)-Rotigotine hydrochloride, (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride, (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride, (-)-Rotigotine hydrochloride, Rotigotine HCl, UNII:6Q1W9573L2

Rotigotine hydrochloride (CAS 125572-93-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C19H26ClNOS and a molecular weight of 351.934 g/mol. Key properties include a melting point of 186.5-187.5ºC, a boiling point of 470.1ºC at 760 mmHg and a flash point of 238.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 125572-93-2
Jingsj CID: J-1980001-2
Molecular Formula: C₁₉H₂₆ClNOS
Molecular Weight: 351.934 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	186.5-187.5ºC
Boiling Point	470.1ºC at 760 mmHg
Flash Point	238.1ºC
Exact Mass	351.142365
PSA	51.71000
LogP	5.06770
Vapor Pressure	1.84E-09mmHg at 25°C
Storage Conditions	2~8℃

Activity & Biological Data

Target	Ki: 0.71 nM (dopamine D3 receptor), 4-15 nM (dopamine D2, D5, D4 receptors), 83 nM (dopamine D1 receptor)[1][2], 176 nM (α1A), 273 nM (α1B), 338 nM (α2A), 27 nM (α2B), 30 nM (5-HT1A), 86 nM (5-HT7)[2]
Additional Information	[1]. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. [2]. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. [3]. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. [4]. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP? and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

Target

Ki: 0.71 nM (dopamine D3 receptor), 4-15 nM (dopamine D2, D5, D4 receptors), 83 nM (dopamine D1 receptor)[1][2], 176 nM (α1A), 273 nM (α1B), 338 nM (α2A), 27 nM (α2B), 30 nM (5-HT1A), 86 nM (5-HT7)[2]

Additional Information

[1]. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. [2]. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. [3]. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. [4]. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP? and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of Rotigotine hydrochloride?

The CAS number of Rotigotine hydrochloride is 125572-93-2.

What are the molecular formula and molecular weight of Rotigotine hydrochloride?

Rotigotine hydrochloride has molecular formula C19H26ClNOS and molecular weight 351.934 g/mol.

What are the upstream and downstream products of Rotigotine hydrochloride?

For Rotigotine hydrochloride, Upstream Products: Rotigotine, 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride, 5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; Downstream Products: Rotigotine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rotigotine hydrochloride (CAS 125572-93-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980001-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.