Rotigotine
Also known as: Neupro, N 0923, SPM 962, (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol, (-)-Rotigotine, (S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol, 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-
Rotigotine (CAS 99755-59-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H25NOS and a molecular weight of 315.473 g/mol. Key properties include a boiling point of 470.1±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 238.1±28.7 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 99755-59-6
- Jingsj CID
- J-1326739-5
- Molecular Formula
- C19H25NOS
- Molecular Weight
- 315.473 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 470.1±45.0 °C at 760 mmHg |
|---|---|
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 238.1±28.7 °C |
| Exact Mass | 315.165680 |
| PSA | 51.71000 |
| LogP | 4.96 |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| Refractive Index | 1.611 |
| Storage Conditions | room temp |
GHS Safety & Compliance
- H302 — Harmful if swallowed
Activity & Biological Data
| Target | Ki: 0.71 nM (dopamine D3 receptor), 4-15 nM (D2, D5, D4 receptors), 83 nM (dopamine D1 receptor)[1][2], 176 nM (α1A), 273 nM (α1B), 338 nM (α2A), 27 nM (α2B), 30 nM (5-HT1A), 86 nM (5-HT7)[2] |
|---|---|
| Additional Information | [1]. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. [2]. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. [3]. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. [4]. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86. |
Customs & Trade Information
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Rotigotine?
The CAS number of Rotigotine is 99755-59-6.
What are the molecular formula and molecular weight of Rotigotine?
Rotigotine has molecular formula C19H25NOS and molecular weight 315.473 g/mol.
Is Rotigotine hazardous?
Rotigotine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.
What are the upstream and downstream products of Rotigotine?
For Rotigotine, Upstream Products: Rotigotine hydrochloride, (6S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol, 2-(2-Thienyl)ethyl 4-methylbenzenesulfonate; Downstream Products: Rotigotine hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Rotigotine (CAS 99755-59-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1326739-5 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.