Sunitinib

Also known as: SU11248, Sutent, N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, MFCD08273555, sunitinibum, Suniti

Sunitinib (CAS 557795-19-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H27FN4O2 and a molecular weight of 398.474 g/mol. Key properties include a melting point of 189-191ºC, a boiling point of 572.1±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 299.8±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 557795-19-4
Jingsj CID: J-1979978-1
Molecular Formula: C₂₂H₂₇FN₄O₂
Molecular Weight: 398.474 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	189-191ºC
Boiling Point	572.1±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	299.8±30.1 °C
Exact Mass	398.211792
PSA	77.23000
LogP	3.15
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.611

Activity & Biological Data

Target	VEGFR2:80 nM (IC50) PDGFRβ:2 nM (IC50)
Additional Information	[1]. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r [2]. Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can [3]. O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. [4]. Azimi MS, et al. An ex vivo model for anti-angiogenic drug testing on intact microvascular networks. PLoS One. 2015 Mar 5;10(3):e0119227.

Target

VEGFR2:80 nM (IC50) PDGFRβ:2 nM (IC50)

Additional Information

[1]. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r [2]. Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can [3]. O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. [4]. Azimi MS, et al. An ex vivo model for anti-angiogenic drug testing on intact microvascular networks. PLoS One. 2015 Mar 5;10(3):e0119227.

Frequently Asked Questions

What is the CAS number of Sunitinib?

The CAS number of Sunitinib is 557795-19-4.

What are the molecular formula and molecular weight of Sunitinib?

Sunitinib has molecular formula C22H27FN4O2 and molecular weight 398.474 g/mol.

What are the upstream and downstream products of Sunitinib?

For Sunitinib, Upstream Products: N,N-Diethylethylenediamine, (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, 5-Fluoro-2-oxindole; Downstream Products: Sunitinib Malate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sunitinib (CAS 557795-19-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1979978-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.