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Trametinib dimethyl sulfoxide

Also known as: GSK1120212 (DMSO solvate), GSK-1120212 dimethyl sulfoxide, GSK1120212B, Trametinib (DMSO solvate), Trametinib DMSO, Trametinib DMSO solvate, JTP-74057, Mekinist, UNII-BSB9VJ5TUT, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1), Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1'-sulfinylbis[methane] (1:1)

Trametinib dimethyl sulfoxide (CAS 1187431-43-1) is a compound in the Sulfur Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H29FIN5O5S and a molecular weight of 693.528 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
1187431-43-1
Jingsj CID
J-1978985-7
Molecular Formula
C28H29FIN5O5S
Molecular Weight
693.528 g/mol
Category
Sulfur Compounds
Last updated
8/21/2026
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Physicochemical Properties

Exact Mass693.091797
PSA146.90000
LogP5.52300
Storage Conditions2-8℃

Activity & Biological Data

TargetMEK1:2 nM (IC50) MEK2:2 nM (IC50)
Additional Information[1]. Yamaguchi T, et al. Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide. Inflamm Res, 2012, 61(5), 445-454. [2]. Abe H, et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med Chem Lett. 2011 Feb 28;2(4):320-4.

Frequently Asked Questions

What is the CAS number of Trametinib dimethyl sulfoxide?

The CAS number of Trametinib dimethyl sulfoxide is 1187431-43-1.

What are the molecular formula and molecular weight of Trametinib dimethyl sulfoxide?

Trametinib dimethyl sulfoxide has molecular formula C28H29FIN5O5S and molecular weight 693.528 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Trametinib dimethyl sulfoxide (CAS 1187431-43-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1978985-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.