Epothilone B

Also known as: Patupilone, EPO906, EpoB, Epothilon B, (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Epothilone B (CAS 152044-54-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C27H41NO6S and a molecular weight of 507.682 g/mol. Key properties include a melting point of 95-97ºC, a boiling point of 680.2±55.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 365.2±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 152044-54-7
Jingsj CID: J-1977754-9
Molecular Formula: C₂₇H₄₁NO₆S
Molecular Weight: 507.682 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	95-97ºC
Boiling Point	680.2±55.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	365.2±31.5 °C
Exact Mass	507.265472
PSA	137.49000
LogP	2.29
Vapor Pressure	0.0±2.2 mmHg at 25°C
Refractive Index	1.532
Storage Conditions	-20°C

Activity & Biological Data

Target	EC0.01: 1.8 μM (Microtubule/Tubulin)[1]
Additional Information	[1]. Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6. [2]. Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. [3]. Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.

Target

EC0.01: 1.8 μM (Microtubule/Tubulin)[1]

Additional Information

[1]. Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6. [2]. Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. [3]. Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.

Frequently Asked Questions

What is the CAS number of Epothilone B?

The CAS number of Epothilone B is 152044-54-7.

What are the molecular formula and molecular weight of Epothilone B?

Epothilone B has molecular formula C27H41NO6S and molecular weight 507.682 g/mol.

What are the upstream and downstream products of Epothilone B?

For Epothilone B, Upstream Products: Epothilone D, 2-Methyl-1,3-thiazole-4-carbaldehyde; Downstream Products: Epothilone D, Ixabepilone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Epothilone B (CAS 152044-54-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1977754-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.