Sofosbuvir

Also known as: GS-7977, PSI-7977, Sovaldi, PSI-7977, Uridine, 2'-deoxy-2'-fluoro-2'-methyl-5'-O-[(S)-[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-, propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate, Isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate

Sofosbuvir (CAS 1190307-88-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H29FN3O9P and a molecular weight of 529.453 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1190307-88-0
Jingsj CID: J-1975343-6
Molecular Formula: C₂₂H₂₉FN₃O₉P
Molecular Weight: 529.453 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	529.162537
PSA	167.99000
LogP	1.62
Refractive Index	1.573
Storage Conditions	-20°C

Activity & Biological Data

Target	EC50: 92±5 nM (HCV)[1]
Additional Information	[1]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47. [2]. Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68. [3]. Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18. [4]. Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

Target

EC50: 92±5 nM (HCV)[1]

Additional Information

[1]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47. [2]. Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68. [3]. Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18. [4]. Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

Frequently Asked Questions

What is the CAS number of Sofosbuvir?

The CAS number of Sofosbuvir is 1190307-88-0.

What are the molecular formula and molecular weight of Sofosbuvir?

Sofosbuvir has molecular formula C22H29FN3O9P and molecular weight 529.453 g/mol.

What are the upstream and downstream products of Sofosbuvir?

For Sofosbuvir, Upstream Products: 2'-deoxy-2'-fluoro-2'-C-methyluridine, (S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate, Sofosbuvir.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sofosbuvir (CAS 1190307-88-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975343-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.