2'-deoxy-2'-fluoro-2'-C-methyluridine

Also known as: PSI-6206, GS-331007, RO 2433, Ro-2433, URI002, 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, 2'-deoxy-2'-fluoro-2'-C-methyl-uridine, Uridine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-

2'-deoxy-2'-fluoro-2'-C-methyluridine (CAS 863329-66-2) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H13FN2O5 and a molecular weight of 260.219 g/mol. Key properties include a melting point of 237-238℃ and a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 863329-66-2
Jingsj CID: J-1957158-5
Molecular Formula: C₁₀H₁₃FN₂O₅
Molecular Weight: 260.219 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	237-238℃
Density	1.6±0.1 g/cm3
Exact Mass	260.080841
PSA	104.55000
LogP	-0.77
Refractive Index	1.596

Activity & Biological Data

Target	EC90：>100 μM (HCV replicon)[1]
Additional Information	[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.

Target

EC90：>100 μM (HCV replicon)[1]

Additional Information

[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 2'-deoxy-2'-fluoro-2'-C-methyluridine?

The CAS number of 2'-deoxy-2'-fluoro-2'-C-methyluridine is 863329-66-2.

What are the molecular formula and molecular weight of 2'-deoxy-2'-fluoro-2'-C-methyluridine?

2'-deoxy-2'-fluoro-2'-C-methyluridine has molecular formula C10H13FN2O5 and molecular weight 260.219 g/mol.

What are the upstream and downstream products of 2'-deoxy-2'-fluoro-2'-C-methyluridine?

For 2'-deoxy-2'-fluoro-2'-C-methyluridine, Upstream Products: (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate; Downstream Products: Sofosbuvir, Sofosbuvir.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2'-deoxy-2'-fluoro-2'-C-methyluridine (CAS 863329-66-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957158-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.