Dihydrolipoic acid

Also known as: (±)-dihydrolipoic acid, 6,8-Dihydrothioctic acid, 6,8-Dimercaptooctanoic acid, 6,8-Disulfanyloctanoic acid, DHLA, DL-6,8-Thioctic acid, reduced, DL-alpha-Lipoic acid reduced form, DL-Dihydrolipoic acid, Reduced lipoic acid, USAF XR-12, Dihydrolipoate, Gamma-Lipoic Acid

Dihydrolipoic acid (CAS 462-20-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H16O2S2 and a molecular weight of 208.341 g/mol. Key properties include a melting point of 60ºC, a boiling point of 360.8±32.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 172.0±25.1 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 462-20-4
Jingsj CID: J-1974870-0
Molecular Formula: C₈H₁₆O₂S₂
Molecular Weight: 208.341 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	60ºC
Boiling Point	360.8±32.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	172.0±25.1 °C
Exact Mass	208.059174
PSA	114.90000
LogP	2.07
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.527
Storage Conditions	+2C to +8C

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Romina Castañeda-Arriaga, et al. Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data. J Chem Inf Model. 2014 Jun 23;54(6):1642-52. [2]. Hetao Bian, et al. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 2020 May 25;17(1):166.

Additional Information

[1]. Romina Castañeda-Arriaga, et al. Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data. J Chem Inf Model. 2014 Jun 23;54(6):1642-52. [2]. Hetao Bian, et al. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 2020 May 25;17(1):166.

Customs & Trade Information

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Dihydrolipoic acid?

The CAS number of Dihydrolipoic acid is 462-20-4.

What are the molecular formula and molecular weight of Dihydrolipoic acid?

Dihydrolipoic acid has molecular formula C8H16O2S2 and molecular weight 208.341 g/mol.

Is Dihydrolipoic acid hazardous?

Dihydrolipoic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Dihydrolipoic acid?

For Dihydrolipoic acid, Downstream Products: 2-Mercaptoethanol, α-Lipoic Acid, DL-Dithiothreitol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Dihydrolipoic acid (CAS 462-20-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974870-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.