α-Lipoic Acid

Also known as: Thioctic acid, DL-Thioctic Acid, alpha-Lipoic acid, ALA, (±)-α-Lipoic acid, 1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, Lipoic acid, DL-6,8-Thioctic acid

α-Lipoic Acid (CAS 1077-28-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H14O2S2 and a molecular weight of 206.326 g/mol. Key properties include a melting point of 60-62ºC, a boiling point of 362.5±11.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 173.0±19.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1077-28-7
Jingsj CID: J-12975-9
Molecular Formula: C₈H₁₄O₂S₂
Molecular Weight: 206.326 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	60-62ºC
Boiling Point	362.5±11.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	173.0±19.3 °C
Exact Mass	206.043518
PSA	87.90000
LogP	2.16
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.562
Additional Property	ethanol: 50 mg/mL \| 0.9 g/L (20 ºC)

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	NF-κB HIV Mitochondrial bioenergetics
Additional Information	[1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. [2]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. [3]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.

Target

NF-κB HIV Mitochondrial bioenergetics

Additional Information

[1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. [2]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. [3]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of α-Lipoic Acid?

The CAS number of α-Lipoic Acid is 1077-28-7.

What are the molecular formula and molecular weight of α-Lipoic Acid?

α-Lipoic Acid has molecular formula C8H14O2S2 and molecular weight 206.326 g/mol.

Is α-Lipoic Acid hazardous?

α-Lipoic Acid has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of α-Lipoic Acid?

For α-Lipoic Acid, Upstream Products: Dihydrolipoic acid, methyl adipoyl chloride; Downstream Products: Lipoamide, 1,3-Dicyclohexylurea, Dihydrolipoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "α-Lipoic Acid (CAS 1077-28-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12975-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.