Erlotinib

Also known as: Erlotinib base, OSI-774, CP-358,774, Ro 50-8231, Tarceva, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline, MFCD07781272, UNII-J4T82NDH7E

Erlotinib (CAS 183321-74-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H23N3O4 and a molecular weight of 393.436 g/mol. Key properties include a melting point of 223 - 228ºC, a boiling point of 553.6±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 288.6±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 183321-74-6
Jingsj CID: J-1971788-5
Molecular Formula: C₂₂H₂₃N₃O₄
Molecular Weight: 393.436 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	223 - 228ºC
Boiling Point	553.6±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	288.6±30.1 °C
Exact Mass	393.168854
PSA	74.73000
LogP	2.39
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.615
Storage Conditions	2~8°C

Activity & Biological Data

Target	EGFR:2 nM (IC50, Cell Free Assay)
Additional Information	[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848. [2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. [3]. Wada Y, et al. Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats. PLoS One. 2014 Nov 12;9(11):e111728.

Target

EGFR:2 nM (IC50, Cell Free Assay)

Additional Information

[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848. [2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. [3]. Wada Y, et al. Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats. PLoS One. 2014 Nov 12;9(11):e111728.

Frequently Asked Questions

What is the CAS number of Erlotinib?

The CAS number of Erlotinib is 183321-74-6.

What are the molecular formula and molecular weight of Erlotinib?

Erlotinib has molecular formula C22H23N3O4 and molecular weight 393.436 g/mol.

What are the upstream and downstream products of Erlotinib?

For Erlotinib, Upstream Products: 6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one, 3-Aminophenylacetylene, Erlotinib hydrochloride; Downstream Products: Erlotinib hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Erlotinib (CAS 183321-74-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971788-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.