Erlotinib hydrochloride

Also known as: Erlotinib HCl, Erlotinib HCl (OSI-744), OSI-774, Tarceva, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, Erlotinib hydrochloride salt, Erlotinib, Hydrochloride Salt, Erlotinib-d6 HCl, MFCD07781272

Erlotinib hydrochloride (CAS 183319-69-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C22H24ClN3O4 and a molecular weight of 429.897 g/mol. Key properties include a melting point of 223-225ºC, a boiling point of 553.6ºC at 760 mmHg and a flash point of 288.6ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 183319-69-9
Jingsj CID: J-1963046-7
Molecular Formula: C₂₂H₂₄ClN₃O₄
Molecular Weight: 429.897 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	223-225ºC
Boiling Point	553.6ºC at 760 mmHg
Flash Point	288.6ºC
Exact Mass	429.145538
PSA	74.73000
LogP	4.28010
Vapor Pressure	4.52E-12mmHg at 25°C
Storage Conditions	-20°C Freezer

Activity & Biological Data

Target	EGFR:2 nM (IC50)
Additional Information	[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. [2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. [3]. Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-typ [4]. Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14.

Target

EGFR:2 nM (IC50)

Additional Information

[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. [2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. [3]. Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-typ [4]. Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Erlotinib hydrochloride?

The CAS number of Erlotinib hydrochloride is 183319-69-9.

What are the molecular formula and molecular weight of Erlotinib hydrochloride?

Erlotinib hydrochloride has molecular formula C22H24ClN3O4 and molecular weight 429.897 g/mol.

What are the upstream and downstream products of Erlotinib hydrochloride?

For Erlotinib hydrochloride, Upstream Products: 3-Aminophenylacetylene, Erlotinib, 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline; Downstream Products: Erlotinib.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Erlotinib hydrochloride (CAS 183319-69-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963046-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.