Emedastine

Also known as: 1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole, 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole, 1-[2-(Ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole, Rapimine, Emadine, AL 3432A, Emedastina, Emedastinum

Emedastine (CAS 87233-61-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H26N4O and a molecular weight of 302.414 g/mol. Key properties include a melting point of 148-151ºC, a boiling point of 446.6±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 223.9±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 87233-61-2
Jingsj CID: J-1968880-3
Molecular Formula: C₁₇H₂₆N₄O
Molecular Weight: 302.414 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	148-151ºC
Boiling Point	446.6±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	223.9±31.5 °C
Exact Mass	302.210663
PSA	33.53000
LogP	3.02
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.595
Storage Conditions	-20℃

Activity & Biological Data

Target	H1 Receptor:1.3 nM (Ki) H2 Receptor:49067 nM (Ki) H3 Receptor:12430 nM (Ki)
Additional Information	[1]. Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10(4):653-64. [2]. Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67. [3]. Andoh T, et al. Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406(1):149-52.

Target

H1 Receptor:1.3 nM (Ki) H2 Receptor:49067 nM (Ki) H3 Receptor:12430 nM (Ki)

Additional Information

[1]. Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10(4):653-64. [2]. Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67. [3]. Andoh T, et al. Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406(1):149-52.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Emedastine?

The CAS number of Emedastine is 87233-61-2.

What are the molecular formula and molecular weight of Emedastine?

Emedastine has molecular formula C17H26N4O and molecular weight 302.414 g/mol.

What are the upstream and downstream products of Emedastine?

For Emedastine, Upstream Products: 1-Methyl-1,4-diazepane, 2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole, 1-chloro-2-nitrobenzene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Emedastine (CAS 87233-61-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1968880-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.