Posaconazole
Also known as: Noxafil, Sch 56592, 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Posaconazole (CAS 171228-49-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C37H42F2N8O4 and a molecular weight of 700.777 g/mol. Key properties include a melting point of 170-1720C, a boiling point of 850.7±75.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 468.3±37.1 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 171228-49-2
- Jingsj CID
- J-1963177-7
- Molecular Formula
- C37H42F2N8O4
- Molecular Weight
- 700.777 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 170-1720C |
|---|---|
| Boiling Point | 850.7±75.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 468.3±37.1 °C |
| Exact Mass | 700.329712 |
| PSA | 115.70000 |
| LogP | 2.25 |
| Vapor Pressure | 0.0±0.3 mmHg at 25°C |
| Refractive Index | 1.658 |
| Storage Conditions | -20°C Freezer |
GHS Safety & Compliance
- H225 — Highly flammable liquid and vapour
- H301 — Toxic if swallowed
- H311 — Toxic in contact with skin
- H331 — Toxic if inhaled
- H370 — Causes damage to organs
Activity & Biological Data
| Additional Information | [1]. Benaim G, et al. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem. 2006 Feb 9;49(3):892-9. [2]. Sabatelli F, et al. In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15. [3]. Sansone-Parsons A, et al. Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers. Antimicrob Agents Chemother. 2006 May;50(5):1881-3. [4]. Veiga-Santos P, et al. Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi. Int J Antimicrob Agents. 2012 Jul;40(1):61-71. [5]. Sun QN, et al. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob Agents Chemother. 2002 Jul;46(7):2310-2. |
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Frequently Asked Questions
What is the CAS number of Posaconazole?
The CAS number of Posaconazole is 171228-49-2.
What are the molecular formula and molecular weight of Posaconazole?
Posaconazole has molecular formula C37H42F2N8O4 and molecular weight 700.777 g/mol.
Is Posaconazole hazardous?
Posaconazole has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.
What are the upstream and downstream products of Posaconazole?
For Posaconazole, Upstream Products: 4-Bromophenol, 2-Chloro-2',4'-difluoroacetophenone, 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Posaconazole (CAS 171228-49-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963177-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.