Vildagliptin

Also known as: Galvus, LAF 237, NVP-LAF 237, (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile, (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile, 2-Pyrrolidinecarbonitrile, 1-[2-[(3-hydroxytricyclo[3.3.1.1]dec-1-yl)amino]acetyl]-, (2S)-

Vildagliptin (CAS 274901-16-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H25N3O2 and a molecular weight of 303.39900 g/mol. Key properties include a melting point of 153-155?C, a boiling point of 531.3ºC at 760 mmHg, a density of 1.27 g/cm3 and a flash point of 275.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 274901-16-5
Jingsj CID: J-1963154-0
Molecular Formula: C₁₇H₂₅N₃O₂
Molecular Weight: 303.39900 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	153-155?C
Boiling Point	531.3ºC at 760 mmHg
Density	1.27 g/cm3
Flash Point	275.1ºC
Exact Mass	303.19500
PSA	76.36000
LogP	1.50308
Storage Conditions	-20°C Freezer

Activity & Biological Data

Additional Information	[1]. Villhauer EB, Brinkman JA, Naderi GB et al. 1-[[(3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-89. [2]. He YL, Kulmatycki K, Zhang Y, Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment. Int J Clin Pharmacol Ther. 2013 Jun 19. [3]. Avila Dde L, Araújo GR, Silva M, Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Arch Med Res. 2013 Apr;44(3):194-202. [4]. Qin CJ, et al. Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2. Cancer Lett. 2018 Jan 31;420:26-37.

Additional Information

[1]. Villhauer EB, Brinkman JA, Naderi GB et al. 1-[[(3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-89. [2]. He YL, Kulmatycki K, Zhang Y, Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment. Int J Clin Pharmacol Ther. 2013 Jun 19. [3]. Avila Dde L, Araújo GR, Silva M, Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Arch Med Res. 2013 Apr;44(3):194-202. [4]. Qin CJ, et al. Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2. Cancer Lett. 2018 Jan 31;420:26-37.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Vildagliptin?

The CAS number of Vildagliptin is 274901-16-5.

What are the molecular formula and molecular weight of Vildagliptin?

Vildagliptin has molecular formula C17H25N3O2 and molecular weight 303.39900 g/mol.

What are the upstream and downstream products of Vildagliptin?

For Vildagliptin, Upstream Products: 3-Amino-1-adamantanol, (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, 2-((3-Hydroxyadamantan-1-yl)amino)acetic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vildagliptin (CAS 274901-16-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963154-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.