Tivozanib
Also known as: AV-951, KRN951, AV 951, AV951, KRN-951, CS-8, 1-{2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea, N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea, Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-
Tivozanib (CAS 475108-18-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H19ClN4O5 and a molecular weight of 454.863 g/mol. Key properties include a boiling point of 550.4±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 286.7±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 475108-18-0
- Jingsj CID
- J-1960022-7
- Molecular Formula
- C22H19ClN4O5
- Molecular Weight
- 454.863 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 550.4±50.0 °C at 760 mmHg |
|---|---|
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 286.7±30.1 °C |
| Exact Mass | 454.104401 |
| PSA | 107.74000 |
| LogP | 4.31 |
| Vapor Pressure | 0.0±1.5 mmHg at 25°C |
| Refractive Index | 1.680 |
| Storage Conditions | -20°C |
Activity & Biological Data
| Target | VEGFR1:30 nM (IC50) VEGFR2:6.5 nM (IC50) VEGFR3:15 nM (IC50) |
|---|---|
| Additional Information | [1]. Nakamura K, et al. KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66(18):9134-42. |
Frequently Asked Questions
What is the CAS number of Tivozanib?
The CAS number of Tivozanib is 475108-18-0.
What are the molecular formula and molecular weight of Tivozanib?
Tivozanib has molecular formula C22H19ClN4O5 and molecular weight 454.863 g/mol.
What are the upstream and downstream products of Tivozanib?
For Tivozanib, Upstream Products: 3-Amino-5-methylisoxazole, Phenyl chloroformate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tivozanib (CAS 475108-18-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1960022-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.