6-Bromoindirubin-3'-oxime

Also known as: BIO, GSK-3 Inhibitor IX, 6BIO, 6-Bromoindirubin-3'-monoxime, (2'Z,3'E)-6-Bromoindirubin-3'-oxime, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, MLS 2052, CS-1934

6-Bromoindirubin-3'-oxime (CAS 667463-62-9) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C16H10BrN3O2 and a molecular weight of 356.173 g/mol. Key properties include a melting point of 300°C(lit.), a boiling point of 554.3±50.0 °C at 760 mmHg, a density of 1.8±0.1 g/cm3 and a flash point of 289.0±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 667463-62-9
Jingsj CID: J-1959943-0
Molecular Formula: C₁₆H₁₀BrN₃O₂
Molecular Weight: 356.173 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	300°C(lit.)
Boiling Point	554.3±50.0 °C at 760 mmHg
Density	1.8±0.1 g/cm3
Flash Point	289.0±30.1 °C
Exact Mass	354.995636
PSA	73.72000
LogP	2.41
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.802

Activity & Biological Data

Target	GSK-3α:5 nM (IC50) GSK-3β:5 nM (IC50) CDK5/p35:80 nM (IC50) Cdk1/cyclin B:320 nM (IC50) cdk2/cyclin A:300 nM (IC50) Cdk4/cyclin D1:10 μM (IC50) MAPKK:10 μM (IC50) protein kinase Cα:12 μM (IC50)
Additional Information	[1]. Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. [2]. Sato N, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004 Jan;10(1):55-63. Epub 2003 Dec 21. [3]. Tseng AS, et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006 Sep;13(9):957-63. [4]. Liu L1, et al. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011 Jun 1;71(11):3972-9

Target

GSK-3α:5 nM (IC50) GSK-3β:5 nM (IC50) CDK5/p35:80 nM (IC50) Cdk1/cyclin B:320 nM (IC50) cdk2/cyclin A:300 nM (IC50) Cdk4/cyclin D1:10 μM (IC50) MAPKK:10 μM (IC50) protein kinase Cα:12 μM (IC50)

Additional Information

[1]. Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. [2]. Sato N, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004 Jan;10(1):55-63. Epub 2003 Dec 21. [3]. Tseng AS, et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006 Sep;13(9):957-63. [4]. Liu L1, et al. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011 Jun 1;71(11):3972-9

Frequently Asked Questions

What is the CAS number of 6-Bromoindirubin-3'-oxime?

The CAS number of 6-Bromoindirubin-3'-oxime is 667463-62-9.

What are the molecular formula and molecular weight of 6-Bromoindirubin-3'-oxime?

6-Bromoindirubin-3'-oxime has molecular formula C16H10BrN3O2 and molecular weight 356.173 g/mol.

What are the upstream and downstream products of 6-Bromoindirubin-3'-oxime?

For 6-Bromoindirubin-3'-oxime, Upstream Products: 6-Bromoisatin, 3-Bromoaniline.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "6-Bromoindirubin-3'-oxime (CAS 667463-62-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959943-0 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.