Sirtinol

Also known as: SIRTINOL, SIR TWO INHIBITOR NAPHTHOL, 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE, 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide, (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide, Benzamide, 2-[[(1E)-(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-

Sirtinol (CAS 410536-97-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C26H22N2O2 and a molecular weight of 394.465 g/mol. Key properties include a melting point of 119-120℃, a boiling point of 659.2±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 352.5±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 410536-97-9
Jingsj CID: J-1959908-7
Molecular Formula: C₂₆H₂₂N₂O₂
Molecular Weight: 394.465 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	119-120℃
Boiling Point	659.2±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	352.5±30.1 °C
Exact Mass	394.168121
PSA	61.69000
LogP	6.20
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.623
Storage Conditions	−20°C
Additional Property	Soluble in water, DMSO and methanol

Activity & Biological Data

Target	ySir2:48 μM (IC50) hSIRT2:57.7 μM (IC50) hSIRT1:131 μM (IC50)
Additional Information	[1]. Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. [2]. Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. [3]. Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. [4]. Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.

Target

ySir2:48 μM (IC50) hSIRT2:57.7 μM (IC50) hSIRT1:131 μM (IC50)

Additional Information

[1]. Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. [2]. Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. [3]. Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. [4]. Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.

Customs & Trade Information

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Sirtinol?

The CAS number of Sirtinol is 410536-97-9.

What are the molecular formula and molecular weight of Sirtinol?

Sirtinol has molecular formula C26H22N2O2 and molecular weight 394.465 g/mol.

What are the upstream and downstream products of Sirtinol?

For Sirtinol, Upstream Products: 2-amino-N-(1-phenylethyl)benzamide, 2-Hydroxy-1-naphthaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sirtinol (CAS 410536-97-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959908-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.