Bendamustine hydrochloride

Also known as: Bendamustine HCl, Bendamustin hydrochloride, 4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid hydrochloride, 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, monohydrochloride, Cytostasan, Treanda, Ribomustin, Levact, SDX-105, ZIMET-33/93

Bendamustine hydrochloride (CAS 3543-75-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C16H22Cl3N3O2 and a molecular weight of 394.724 g/mol. Key property: a melting point of 149-151°C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 3543-75-7
Jingsj CID: J-1959053-5
Molecular Formula: C₁₆H₂₂Cl₃N₃O₂
Molecular Weight: 394.724 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	149-151°C
Exact Mass	393.077759
PSA	58.36000
LogP	4.06660
Storage Conditions	Desiccate at RT

Activity & Biological Data

Target	DNA Alkylator/Crosslinker[1]
Additional Information	[1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. [2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. [3]. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. [4]. Minbo Zang, et al. Effects of chemotherapeutic agent bendamustine for non-hodgkin lymphoma on spermatogenesis in mice. J Biomed Res. 2017 0(0): 1-12.

Target

DNA Alkylator/Crosslinker[1]

Additional Information

[1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. [2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. [3]. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. [4]. Minbo Zang, et al. Effects of chemotherapeutic agent bendamustine for non-hodgkin lymphoma on spermatogenesis in mice. J Biomed Res. 2017 0(0): 1-12.

Frequently Asked Questions

What is the CAS number of Bendamustine hydrochloride?

The CAS number of Bendamustine hydrochloride is 3543-75-7.

What are the molecular formula and molecular weight of Bendamustine hydrochloride?

Bendamustine hydrochloride has molecular formula C16H22Cl3N3O2 and molecular weight 394.724 g/mol.

What are the upstream and downstream products of Bendamustine hydrochloride?

For Bendamustine hydrochloride, Upstream Products: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester, Methyl 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoate, N-Methyl-2,4-dinitroaniline; Downstream Products: Methyl 4-(5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl)butanoate, Bendamustine, Methyl 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Bendamustine hydrochloride (CAS 3543-75-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959053-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.