Rociletinib
Also known as: CO-1686, CO 1686, AVL-301, CNX-419, CO-1686 (AVL-301), CO-1686 (free base), Rociletinib (CO-1686), N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide, N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)prop-2-enamide, N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide, 2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, UNII: 72AH61702G
Rociletinib (CAS 1374640-70-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C27H28F3N7O3 and a molecular weight of 555.552 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1374640-70-6
- Jingsj CID
- J-1958500-3
- Molecular Formula
- C27H28F3N7O3
- Molecular Weight
- 555.552 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Exact Mass | 555.220581 |
| PSA | 118.44000 |
| LogP | 2.38 |
| Refractive Index | 1.632 |
| Storage Conditions | -20°C |
Activity & Biological Data
| Target | EGFRL858R/T790M:21.5 nM (Ki) EGFRT790M:303.3 nM (Ki) |
|---|---|
| Additional Information | [1]. Walter AO, et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Sep 25. |
Frequently Asked Questions
What is the CAS number of Rociletinib?
The CAS number of Rociletinib is 1374640-70-6.
What are the molecular formula and molecular weight of Rociletinib?
Rociletinib has molecular formula C27H28F3N7O3 and molecular weight 555.552 g/mol.
What are the upstream and downstream products of Rociletinib?
For Rociletinib, Upstream Products: tert-Butyl N-(3-aminophenyl)carbamate, 2,4-Dichloro-5-(trifluoromethyl)pyrimidine, tert-Butyl (3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)carbamate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Rociletinib (CAS 1374640-70-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958500-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.