Levomefolic acid

Also known as: (6S)-5-Methyltetrahydrofolic acid, 5-Methyltetrahydrofolate, 5-methyltetrahydrofolic acid, L-5-Methyltetrahydrofolate, L-5-methyltetrahydrofolic acid, N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid

Levomefolic acid (CAS 31690-09-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C20H25N7O6 and a molecular weight of 459.456 g/mol. Key property: a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 31690-09-2
Jingsj CID: J-1958258-2
Molecular Formula: C₂₀H₂₅N₇O₆
Molecular Weight: 459.456 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.6±0.1 g/cm3
Exact Mass	459.186646
PSA	202.77000
LogP	-2.61
Refractive Index	1.733

Activity & Biological Data

Additional Information	[1]. Hirsch S, Miranda D, Mu?oz E, et al. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2. [2]. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54. [3]. Merola N, Alonso FJ, Ros G, Castón MJ. Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8. [4]. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43. [5]. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605. [6]. Levomefolic acid

Additional Information

[1]. Hirsch S, Miranda D, Mu?oz E, et al. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2. [2]. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54. [3]. Merola N, Alonso FJ, Ros G, Castón MJ. Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8. [4]. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43. [5]. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605. [6]. Levomefolic acid

Frequently Asked Questions

What is the CAS number of Levomefolic acid?

The CAS number of Levomefolic acid is 31690-09-2.

What are the molecular formula and molecular weight of Levomefolic acid?

Levomefolic acid has molecular formula C20H25N7O6 and molecular weight 459.456 g/mol.

What are the upstream and downstream products of Levomefolic acid?

For Levomefolic acid, Upstream Products: Folic Acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Levomefolic acid (CAS 31690-09-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958258-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.