PF-543

Also known as: PF-543, PF 543, PF543, (2R)-1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol, 2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)-, [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol, Sphingosine Kinase 1 Inhibitor II, PF-543 - Calbiochem, CS-745, cs-0869

PF-543 (CAS 1415562-82-1) is a compound in the Solvents category listed in the Jingsj chemical database. It has the molecular formula C27H31NO4S and a molecular weight of 465.604 g/mol. Key properties include a boiling point of 666.0±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 356.6±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1415562-82-1
Jingsj CID: J-1957713-3
Molecular Formula: C₂₇H₃₁NO₄S
Molecular Weight: 465.604 g/mol
Category: Solvents
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	666.0±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	356.6±31.5 °C
Exact Mass	465.197388
PSA	75.22000
LogP	4.16
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.610
Storage Conditions	-20℃

Activity & Biological Data

Target	Ki: 3.6 nM (SPHK1)[1]
Additional Information	[1]. Schnute ME, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88. [2]. Wang J, et al. Crystal Structure of Sphingosine Kinase 1 with PF-543. ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33. [3]. MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55.

Target

Ki: 3.6 nM (SPHK1)[1]

Additional Information

[1]. Schnute ME, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88. [2]. Wang J, et al. Crystal Structure of Sphingosine Kinase 1 with PF-543. ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33. [3]. MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55.

Frequently Asked Questions

What is the CAS number of PF-543?

The CAS number of PF-543 is 1415562-82-1.

What are the molecular formula and molecular weight of PF-543?

PF-543 has molecular formula C27H31NO4S and molecular weight 465.604 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "PF-543 (CAS 1415562-82-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957713-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.