Cabozantinib

Also known as: XL184, XL-184, BMS-907351, Cometriq, N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide, 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-, UNII-1C39JW444G

Cabozantinib (CAS 849217-68-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H24FN3O5 and a molecular weight of 501.506 g/mol. Key properties include a boiling point of 758.1±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 412.3±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 849217-68-1
Jingsj CID: J-1957488-0
Molecular Formula: C₂₈H₂₄FN₃O₅
Molecular Weight: 501.506 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	758.1±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	412.3±32.9 °C
Exact Mass	501.170013
PSA	98.78000
LogP	4.84
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.688

Activity & Biological Data

Target	VEGFR2:0.035 nM (IC50) Flt-1:12 nM (IC50) Flt-4:6 nM (IC50) FLT3:11.3 nM (IC50) c-Met:1.3 nM (IC50) c-Kit:4 nM (IC50)
Additional Information	[1]. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. [2]. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308. [3]. Fuse MA, et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398.

Target

VEGFR2:0.035 nM (IC50) Flt-1:12 nM (IC50) Flt-4:6 nM (IC50) FLT3:11.3 nM (IC50) c-Met:1.3 nM (IC50) c-Kit:4 nM (IC50)

Additional Information

[1]. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. [2]. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308. [3]. Fuse MA, et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398.

Customs & Trade Information

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Cabozantinib?

The CAS number of Cabozantinib is 849217-68-1.

What are the molecular formula and molecular weight of Cabozantinib?

Cabozantinib has molecular formula C28H24FN3O5 and molecular weight 501.506 g/mol.

What are the upstream and downstream products of Cabozantinib?

For Cabozantinib, Upstream Products: N-(4-Fluorophenyl)-N'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide, 4-Fluoroaniline, 1,1-Cyclopropanedicarboxylic acid; Downstream Products: Cabozantinib S-malate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cabozantinib (CAS 849217-68-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957488-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.