Cabozantinib S-malate

Also known as: Cabozantinib malate, Cabozantinib (S)-malate, XL184, XL-184, Cometriq, N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate], Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1), (2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1), Cabozantinib L-malate, UNII-DR7ST46X58

Cabozantinib S-malate (CAS 1140909-48-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C32H30FN3O10 and a molecular weight of 635.593 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1140909-48-3
Jingsj CID: J-1957485-7
Molecular Formula: C₃₂H₃₀FN₃O₁₀
Molecular Weight: 635.593 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	635.191528
PSA	193.61000
LogP	4.59340

Activity & Biological Data

Target	VEGFR2:0.035 nM (IC50)
Additional Information	[1]. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. [2]. Torres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res, 2011, 17(12), 3943-3955. [3]. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.

Target

VEGFR2:0.035 nM (IC50)

Additional Information

[1]. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. [2]. Torres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res, 2011, 17(12), 3943-3955. [3]. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.

Frequently Asked Questions

What is the CAS number of Cabozantinib S-malate?

The CAS number of Cabozantinib S-malate is 1140909-48-3.

What are the molecular formula and molecular weight of Cabozantinib S-malate?

Cabozantinib S-malate has molecular formula C32H30FN3O10 and molecular weight 635.593 g/mol.

What are the upstream and downstream products of Cabozantinib S-malate?

For Cabozantinib S-malate, Upstream Products: L-(-)-Malic acid, Cabozantinib, 6,7-Dimethoxyquinolin-4-ol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cabozantinib S-malate (CAS 1140909-48-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957485-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.