Nintedanib esylate

Also known as: Nintedanib ethanesulfonate, Nintedanib ethanesulfonate salt, BIBF 1120 esylate, BIBF-1120 esylate, Vargatef, Ofev, UNII:42F62RTZ4G, 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone monoethanesulfonate salt, Methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate

Nintedanib esylate (CAS 656247-18-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C33H39N5O7S and a molecular weight of 649.757 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 656247-18-6
Jingsj CID: J-1957395-6
Molecular Formula: C₃₃H₃₉N₅O₇S
Molecular Weight: 649.757 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	649.257019
PSA	160.46000
LogP	4.62470
Storage Conditions	-20℃

Activity & Biological Data

Target	VEGFR1:34 nM (IC50) VEGFR2:13 nM (IC50) VEGFR3:13 nM (IC50) FGFR1:69 nM (IC50) FGFR2:37 nM (IC50) FGFR3:108 nM (IC50) PDGFRα:59 nM (IC50) PDGFRβ:65 nM (IC50)
Additional Information	[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. [2]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480. [3]. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130.

Target

VEGFR1:34 nM (IC50) VEGFR2:13 nM (IC50) VEGFR3:13 nM (IC50) FGFR1:69 nM (IC50) FGFR2:37 nM (IC50) FGFR3:108 nM (IC50) PDGFRα:59 nM (IC50) PDGFRβ:65 nM (IC50)

Additional Information

[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. [2]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480. [3]. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130.

Frequently Asked Questions

What is the CAS number of Nintedanib esylate?

The CAS number of Nintedanib esylate is 656247-18-6.

What are the molecular formula and molecular weight of Nintedanib esylate?

Nintedanib esylate has molecular formula C33H39N5O7S and molecular weight 649.757 g/mol.

What are the upstream and downstream products of Nintedanib esylate?

For Nintedanib esylate, Upstream Products: Nintedanib, Ethanesulfonic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nintedanib esylate (CAS 656247-18-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957395-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.