Nintedanib

Also known as: BIBF 1120, BIBF-1120, Vargatef, Ofev, Intedanib, Methyl (3Z)-3-{[(4-{methyl[(4-methyl-1-piperazinyl)acetyl]amino}phenyl)amino](phenyl)methylene}-2-oxo-6-indolinecarboxylate

Nintedanib (CAS 656247-17-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C31H33N5O4 and a molecular weight of 539.625 g/mol. Key properties include a boiling point of 742.2±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 402.7±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 656247-17-5
Jingsj CID: J-1643-3
Molecular Formula: C₃₁H₃₃N₅O₄
Molecular Weight: 539.625 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	742.2±60.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	402.7±32.9 °C
Exact Mass	539.253235
PSA	94.22000
LogP	2.59
Vapor Pressure	0.0±2.5 mmHg at 25°C
Refractive Index	1.658

Activity & Biological Data

Target	VEGFR1:34 nM (IC50) VEGFR2:13 nM (IC50) VEGFR3:13 nM (IC50) FGFR1:69 nM (IC50) FGFR2:37 nM (IC50) FGFR3:108 nM (IC50) PDGFRα:59 nM (IC50) PDGFRβ:65 nM (IC50)
Additional Information	[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. [2]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480. [3]. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130.

Target

VEGFR1:34 nM (IC50) VEGFR2:13 nM (IC50) VEGFR3:13 nM (IC50) FGFR1:69 nM (IC50) FGFR2:37 nM (IC50) FGFR3:108 nM (IC50) PDGFRα:59 nM (IC50) PDGFRβ:65 nM (IC50)

Additional Information

[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. [2]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480. [3]. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130.

Frequently Asked Questions

What is the CAS number of Nintedanib?

The CAS number of Nintedanib is 656247-17-5.

What are the molecular formula and molecular weight of Nintedanib?

Nintedanib has molecular formula C31H33N5O4 and molecular weight 539.625 g/mol.

What are the upstream and downstream products of Nintedanib?

For Nintedanib, Upstream Products: N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide, Methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate, N-Methyl-4-nitroaniline; Downstream Products: Nintedanib esylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nintedanib (CAS 656247-17-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1643-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.