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Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

Also known as: (2R,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride, cis-4-Hydroxy-D-proline methyl ester hydrochloride, Cis-D-Hyp-OMe.HCl, D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-, Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (CAS 114676-59-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C6H12ClNO3 and a molecular weight of 181.617 g/mol. Key property: a melting point of 121-123 ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
114676-59-4
Jingsj CID
J-1957191-6
Molecular Formula
C6H12ClNO3
Molecular Weight
181.617 g/mol
Category
Organic Acids
Last updated
8/21/2026
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Physicochemical Properties

Melting Point121-123 ºC
Exact Mass181.050568
PSA58.56000
LogP0.01300

Activity & Biological Data

TargetNon-cleavable
Additional Information[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Frequently Asked Questions

What is the CAS number of Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride?

The CAS number of Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride is 114676-59-4.

What are the molecular formula and molecular weight of Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride?

Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride has molecular formula C6H12ClNO3 and molecular weight 181.617 g/mol.

What are the upstream and downstream products of Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride?

For Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride, Upstream Products: Methanol, cis-4-Hydroxy-D-proline, cis-4-Hydroxy-D-proline hydrochloride; Downstream Products: tert-butyl (2R,4R)-2-(fluoromethyl)-4-hydroxypyrrolidine-1-carboxylate, N-Boc-4-oxo-D-proline methyl ester, (2R,4S)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (CAS 114676-59-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957191-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.