Tenofovir alafenamide
Also known as: GS-7340, GS7340, TAF, Tenofovir alafenamide free base, propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate, (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate, Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate, Sp-Tenofovir-phosphonamidate,phenyl,L-alanine isopropyl ester
Tenofovir alafenamide (CAS 379270-37-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C21H29N6O5P and a molecular weight of 476.466 g/mol. Key properties include a boiling point of 640.4±65.0 °C at 760 mmHg, a density of 1.39±0.1 g/cm3 and a flash point of 341.1±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 379270-37-8
- Jingsj CID
- J-1957155-3
- Molecular Formula
- C21H29N6O5P
- Molecular Weight
- 476.466 g/mol
- Category
- Organic Bases
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 640.4±65.0 °C at 760 mmHg |
|---|---|
| Density | 1.39±0.1 g/cm3 |
| Flash Point | 341.1±34.3 °C |
| Exact Mass | 476.193695 |
| PSA | 153.29000 |
| LogP | 2.20 |
| Vapor Pressure | 0.0±1.9 mmHg at 25°C |
| Refractive Index | 1.630 |
| Additional Property | Practically insoluble (0.04 g/L) (25 ºC) |
Activity & Biological Data
| Target | HIV-1, NRTIs[1] |
|---|---|
| Additional Information | [1]. Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66. [2]. Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55. |
Frequently Asked Questions
What is the CAS number of Tenofovir alafenamide?
The CAS number of Tenofovir alafenamide is 379270-37-8.
What are the molecular formula and molecular weight of Tenofovir alafenamide?
Tenofovir alafenamide has molecular formula C21H29N6O5P and molecular weight 476.466 g/mol.
What are the upstream and downstream products of Tenofovir alafenamide?
For Tenofovir alafenamide, Upstream Products: L-Alanine isopropyl ester hydrochloride, Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate, Tenofovir.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tenofovir alafenamide (CAS 379270-37-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957155-3 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.