Humulone

Also known as: (R)-Humulone, α-Lupulic acid, α-Bitter acid, Humulon, 2,4-Cyclohexadien-1-one, 3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methyl-2-butenyl)-, (R)-(-)-, 2,4-Cyclohexadien-1-one, 3,5,6-trihydroxy-4,6-bis(3-methyl-2-buten-1-yl)-2-(3-methyl-1-oxobutyl)-, (6R)-, (6R)-3,5,6-Trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-en-1-yl)cyclohexa-2,4-dien-1-one, (6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one, Humulone, mixture of homologues, α-Bitter acid, α-Lupulic acid

Humulone (CAS 26472-41-3) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C21H30O5 and a molecular weight of 362.460 g/mol. Key properties include a melting point of 65-66.5℃, a boiling point of 571.4±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 313.4±26.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 26472-41-3
Jingsj CID: J-1956622-1
Molecular Formula: C₂₁H₃₀O₅
Molecular Weight: 362.460 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	65-66.5℃
Boiling Point	571.4±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	313.4±26.6 °C
Exact Mass	362.209320
PSA	94.83000
LogP	5.14
Vapor Pressure	0.0±3.6 mmHg at 25°C
Refractive Index	1.558

Activity & Biological Data

Target	COX-2
Additional Information	[1]. K Yamamoto, et al. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Lett. 2000 Jan 14;465(2-3):103-6. [2]. Ali Y Benkherouf, et al. Humulone Modulation of GABA A Receptors and Its Role in Hops Sleep-Promoting Activity. Front Neurosci. 2020 Oct 14;14:594708. [3]. Jung-Chul Lee, et al. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis. 2007 Jul;28(7):1491-8.

Target

COX-2

Additional Information

[1]. K Yamamoto, et al. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Lett. 2000 Jan 14;465(2-3):103-6. [2]. Ali Y Benkherouf, et al. Humulone Modulation of GABA A Receptors and Its Role in Hops Sleep-Promoting Activity. Front Neurosci. 2020 Oct 14;14:594708. [3]. Jung-Chul Lee, et al. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis. 2007 Jul;28(7):1491-8.

Frequently Asked Questions

What is the CAS number of Humulone?

The CAS number of Humulone is 26472-41-3.

What are the molecular formula and molecular weight of Humulone?

Humulone has molecular formula C21H30O5 and molecular weight 362.460 g/mol.

What are the upstream and downstream products of Humulone?

For Humulone, Downstream Products: 4-Methyl-3-pentenoic acid, Isobutyraldehyde, isopentane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Humulone (CAS 26472-41-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956622-1 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.