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Tubastatin A

Also known as: Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1), N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide, N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide Tubastatin A, N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide, N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride (1:1), N-hydroxy-4-((2-methyl-2,3,4,5-tetrahydro-1H-indeno[1,2-c]pyridin-5-yl)methyl)benzamide, N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide, N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, TSLDASIIWAMMQN, Tubastatin A BASE, Tubastatin A(free base), Tubastatin-A

Tubastatin A (CAS 1252003-15-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H21N3O2 and a molecular weight of 335.40700 g/mol. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.
1252003-15-8
Jingsj CID
J-1956568-5
Molecular Formula
C20H21N3O2
Molecular Weight
335.40700 g/mol
Category
Organic Compounds
Last updated
11/2/2026
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Physicochemical Properties

Exact Mass371.140045
PSA57.50000
LogP3.12530
Storage Conditions2~8°C

Activity & Biological Data

TargetHDAC6:15 nM (IC50) HDAC8:854 nM (IC50) HDAC1:16400 nM (IC50)
Additional Information[1]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846 [2]. de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. [3]. Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563 [4]. Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9. [5]. Kozyreva VK, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93. [6]. Brijmohan, Angela, et al. Role of HDAC6 in Transcription Factor EB Mediated Clearance of Misfolded Proteins in Chronic Kidney Disease. University of Toronto.Nov-2017.

Frequently Asked Questions

What is the CAS number of Tubastatin A?

The CAS number of Tubastatin A is 1252003-15-8.

What are the molecular formula and molecular weight of Tubastatin A?

Tubastatin A has molecular formula C20H21N3O2 and molecular weight 335.40700 g/mol.

What are the upstream and downstream products of Tubastatin A?

For Tubastatin A, Downstream Products: Tubastatin A trifluoroacetate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Tubastatin A (CAS 1252003-15-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956568-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.