Tubastatin A trifluoroacetate

Also known as: Tubastatin A Trifluoroacetic Acid Salt, Tubastatin A TFA, Tubastatin A trifluoroacetate, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide 2,2,2-trifluoroacetate, N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-trifluoroacetate, Tubastatin A, Tubastantin A, Tubastain A, Tubastatin A HCl, Tubastatin A_HCl, Tubaststina HCl

Tubastatin A trifluoroacetate (CAS 1239262-52-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C22H22F3N3O4 and a molecular weight of 449.42 g/mol. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1239262-52-2
Jingsj CID: J-1003881-0
Molecular Formula: C₂₂H₂₂F₃N₃O₄
Molecular Weight: 449.42 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.3±0.1 g/cm3
Exact Mass	335.163391
PSA	94.80000
LogP	2.14
Refractive Index	1.668

Activity & Biological Data

Target	IC50: 15 nM (HDAC6)[1]
Additional Information	[1]. de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. [2]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846 [3]. Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563 [4]. Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9. [5]. Brijmohan AS, et al. HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease. Front Pharmacol. 2018 Feb 1;9:34. [6]. Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

Target

IC50: 15 nM (HDAC6)[1]

Additional Information

[1]. de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. [2]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846 [3]. Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563 [4]. Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9. [5]. Brijmohan AS, et al. HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease. Front Pharmacol. 2018 Feb 1;9:34. [6]. Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

Frequently Asked Questions

What is the CAS number of Tubastatin A trifluoroacetate?

The CAS number of Tubastatin A trifluoroacetate is 1239262-52-2.

What are the molecular formula and molecular weight of Tubastatin A trifluoroacetate?

Tubastatin A trifluoroacetate has molecular formula C22H22F3N3O4 and molecular weight 449.42 g/mol.

What are the upstream and downstream products of Tubastatin A trifluoroacetate?

For Tubastatin A trifluoroacetate, Upstream Products: Trifluoroacetic acid, 1-Methyl-4-piperidone, Phenylhydrazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tubastatin A trifluoroacetate (CAS 1239262-52-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1003881-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.