Ezetimibe

Also known as: Zetia, Ezetrol, SCH 60969, (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one, Ezetimide, Ezatimibe, MFCD00937872, zetia/vytorin

Ezetimibe (CAS 163222-33-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H21F2NO3 and a molecular weight of 409.425 g/mol. Key properties include a melting point of 164-166â„ƒ, a boiling point of 654.9±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 349.9±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 163222-33-1
Jingsj CID: J-1955710-9
Molecular Formula: C₂₄H₂₁F₂NO₃
Molecular Weight: 409.425 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	164-166â„ƒ
Boiling Point	654.9±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	349.9±31.5 °C
Exact Mass	409.148956
PSA	60.77000
LogP	3.26
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.624
Storage Conditions	-20?C Freezer

Activity & Biological Data

Target	NPC1L1, Nrf2[1]
Additional Information	[1]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [2]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ezetimibe?

The CAS number of Ezetimibe is 163222-33-1.

What are the molecular formula and molecular weight of Ezetimibe?

Ezetimibe has molecular formula C24H21F2NO3 and molecular weight 409.425 g/mol.

What are the upstream and downstream products of Ezetimibe?

For Ezetimibe, Upstream Products: Ezetimibe Ketone, 4'-O-Benzyloxy Ezetimibe, (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ezetimibe (CAS 163222-33-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955710-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.