Ezetimibe Ketone

Also known as: Ezetimibe Ketone, (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one, EZM-K, Ezetimibe 3-Oxo Impurity, Ezetimibe Impurity A, Ezetimibe Intermediate-X, SCH-57871, 1-(4-Fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3-oxopropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-, UNII-9D3ASE5ZPY

Ezetimibe Ketone (CAS 191330-56-0) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C24H19F2NO3 and a molecular weight of 407.409 g/mol. Key properties include a boiling point of 656.1±55.0 °C at 760 mmHg, a density of 1.325 and a flash point of 350.6±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 191330-56-0
Jingsj CID: J-1955225-1
Molecular Formula: C₂₄H₁₉F₂NO₃
Molecular Weight: 407.409 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	656.1±55.0 °C at 760 mmHg
Density	1.325
Flash Point	350.6±31.5 °C
Exact Mass	407.133301
PSA	57.61000
LogP	3.79
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.615

Activity & Biological Data

Target	NPC1L1, Nrf2[1]
Additional Information	[1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Target

NPC1L1, Nrf2[1]

Additional Information

[1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Frequently Asked Questions

What is the CAS number of Ezetimibe Ketone?

The CAS number of Ezetimibe Ketone is 191330-56-0.

What are the molecular formula and molecular weight of Ezetimibe Ketone?

Ezetimibe Ketone has molecular formula C24H19F2NO3 and molecular weight 407.409 g/mol.

What are the upstream and downstream products of Ezetimibe Ketone?

For Ezetimibe Ketone, Upstream Products: (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one, (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid methyl ester, Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate; Downstream Products: 4'-O-Benzyloxy Ezetimibe, Ezetimibe, (3'R)-Ezetimibe.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ezetimibe Ketone (CAS 191330-56-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955225-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.