Phenylephrine hydrochloride

Also known as: (R)-(-)-Phenylephrine hydrochloride, L(-)-Phenylephrine hydrochloride, (-)-3-[1(R)-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride, L-1-(m-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol hydrochloride, Mezaton, Isophrin, AK-Dilate, AK-Nefrin, m-Sympatol

Phenylephrine hydrochloride (CAS 61-76-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C9H14ClNO2 and a molecular weight of 203.666 g/mol. Key properties include a melting point of 143-145 °C(lit.), a boiling point of 341.1ºC at 760 mmHg and a flash point of 163.4ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 61-76-7
Jingsj CID: J-19543-7
Molecular Formula: C₉H₁₄ClNO₂
Molecular Weight: 203.666 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	143-145 °C(lit.)
Boiling Point	341.1ºC at 760 mmHg
Flash Point	163.4ºC
Exact Mass	203.071304
PSA	52.49000
LogP	1.83790
Refractive Index	-45.5 ° (C=1, H2O)
Additional Property	>=10 g/100 mL at 21 ºC

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	pKi: 5.86 (α1D), 5.86 (α1B), 5.86 (α1A)[1]
Additional Information	[1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.

Target

pKi: 5.86 (α1D), 5.86 (α1B), 5.86 (α1A)[1]

Additional Information

[1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.

Customs & Trade Information

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Phenylephrine hydrochloride?

The CAS number of Phenylephrine hydrochloride is 61-76-7.

What are the molecular formula and molecular weight of Phenylephrine hydrochloride?

Phenylephrine hydrochloride has molecular formula C9H14ClNO2 and molecular weight 203.666 g/mol.

Is Phenylephrine hydrochloride hazardous?

Phenylephrine hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Phenylephrine hydrochloride?

For Phenylephrine hydrochloride, Upstream Products: 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride, Phenylephrine, 1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride; Downstream Products: (R)-5-(3-Hydroxyphenyl)-3-methyl-2-oxazolidinone, Phenylephrine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Phenylephrine hydrochloride (CAS 61-76-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-19543-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.