Topotecan
Also known as: Topotecan, (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, Hycamtin
Topotecan (CAS 123948-87-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H23N3O5 and a molecular weight of 421.446 g/mol. Key properties include a melting point of −114 °C(lit.), a boiling point of 782.9±60.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 427.3±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 123948-87-8
- Jingsj CID
- J-19327-1
- Molecular Formula
- C23H23N3O5
- Molecular Weight
- 421.446 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | −114 °C(lit.) |
|---|---|
| Boiling Point | 782.9±60.0 °C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Flash Point | 427.3±32.9 °C |
| Exact Mass | 421.163757 |
| PSA | 104.89000 |
| LogP | 1.08 |
| Additional Property | 1.3 (vs air) |
| Vapor Pressure | 0.0±2.8 mmHg at 25°C |
| Refractive Index | 1.734 |
| Storage Conditions | 2-8°C |
| Additional Property | H2O: soluble |
Activity & Biological Data
| Target | Topoisomerase I |
|---|---|
| Additional Information | [1]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [2]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67. |
Customs & Trade Information
| HS Code | 2942000000 |
|---|
Frequently Asked Questions
What is the CAS number of Topotecan?
The CAS number of Topotecan is 123948-87-8.
What are the molecular formula and molecular weight of Topotecan?
Topotecan has molecular formula C23H23N3O5 and molecular weight 421.446 g/mol.
What are the upstream and downstream products of Topotecan?
For Topotecan, Upstream Products: (S)-10-Hydroxycamptothecin, Eschenmoser's salt, Dichloromethane; Downstream Products: Topotecan hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Topotecan (CAS 123948-87-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-19327-1 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.