Topotecan hydrochloride

Also known as: Topotecan HCl, Hycamtin, SKF-104864-A, NSC 609669, Topotecan hydrochloride, (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride, Topotecan monohydrochloride, Nogitecan hydrochloride

Topotecan hydrochloride (CAS 119413-54-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C23H24ClN3O5 and a molecular weight of 457.91400 g/mol. Key properties include a melting point of 213-218ºC, a boiling point of 782.9±60.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 427.3±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 119413-54-6
Jingsj CID: J-1324376-0
Molecular Formula: C₂₃H₂₄ClN₃O₅
Molecular Weight: 457.91400 g/mol
Category: Organic Acids
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	213-218ºC
Boiling Point	782.9±60.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	427.3±32.9 °C
Exact Mass	421.163757
PSA	104.89000
LogP	1.08
Vapor Pressure	0.0±2.8 mmHg at 25°C
Refractive Index	1.734
Storage Conditions	Refrigerator

Activity & Biological Data

Target	Topoisomerase I
Additional Information	[1]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [2]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of Topotecan hydrochloride?

The CAS number of Topotecan hydrochloride is 119413-54-6.

What are the molecular formula and molecular weight of Topotecan hydrochloride?

Topotecan hydrochloride has molecular formula C23H24ClN3O5 and molecular weight 457.91400 g/mol.

What are the upstream and downstream products of Topotecan hydrochloride?

For Topotecan hydrochloride, Upstream Products: Dichloromethane, (S)-10-Hydroxycamptothecin, Dimethylamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Topotecan hydrochloride (CAS 119413-54-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1324376-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.