Tetrahydroberberine
Also known as: Canadine, THB, (±)-Canadine, dl-Canadine, 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine, 5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo[a,g]quinolizine, 6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, 9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline, Berberine, tetrahydro-, Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-, Nsc94918, UNII:V2SSH085X8
Tetrahydroberberine (CAS 522-97-4) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C20H21NO4 and a molecular weight of 339.385 g/mol. Key properties include a boiling point of 476.1±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 141.1±25.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 522-97-4
- Jingsj CID
- J-18882-9
- Molecular Formula
- C20H21NO4
- Molecular Weight
- 339.385 g/mol
- Category
- Organic Bases
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 476.1±45.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 141.1±25.9 °C |
| Exact Mass | 339.147064 |
| PSA | 40.16000 |
| LogP | 3.83 |
| Appearance | solid | yellow |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| Refractive Index | 1.656 |
| Storage Conditions | 2-8°C |
| Additional Property | DMSO: >10 mg/mL, soluble |
Activity & Biological Data
| Additional Information | [1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36. |
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Frequently Asked Questions
What is the CAS number of Tetrahydroberberine?
The CAS number of Tetrahydroberberine is 522-97-4.
What are the molecular formula and molecular weight of Tetrahydroberberine?
Tetrahydroberberine has molecular formula C20H21NO4 and molecular weight 339.385 g/mol.
What are the upstream and downstream products of Tetrahydroberberine?
For Tetrahydroberberine, Upstream Products: Formaldehyde; Downstream Products: Dihydroberberine, Dihydrochelerythrine, Allocryptopine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tetrahydroberberine (CAS 522-97-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18882-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.