6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

Also known as: AMI-1 free acid, T22239, 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid), 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid), 7,7'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid), 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid], 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid), N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea, N,N'-bis(4-hydroxy-2-sulfonaphthalen-7-yl)urea, phosgenated, EINECS 205-142-9

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) (CAS 134-47-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H16N2O9S2 and a molecular weight of 504.49000 g/mol. Key properties include a melting point of 86-88 °C and a density of 1.798 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 134-47-4
Jingsj CID: J-14421-2
Molecular Formula: C₂₁H₁₆N₂O₉S₂
Molecular Weight: 504.49000 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	86-88 °C
Density	1.798 g/cm3
Exact Mass	504.03000
PSA	207.09000
LogP	5.84920
Refractive Index	-45 ° (C=1, AcOH)

Activity & Biological Data

Target	IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p)[1]
Additional Information	[1]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [2]. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. [3]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [4]. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166.

Target

IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p)[1]

Additional Information

[1]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [2]. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. [3]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [4]. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)?

The CAS number of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) is 134-47-4.

What are the molecular formula and molecular weight of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)?

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) has molecular formula C21H16N2O9S2 and molecular weight 504.49000 g/mol.

What are the upstream and downstream products of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)?

For 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid), Upstream Products: Bis(trichloromethyl) carbonate, 7-amino-4-hydroxy-2-naphthalenesulfonic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) (CAS 134-47-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-14421-2 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.