Pyridone 6

Also known as: JAK Inhibitor I, Merck 5, CS-665, IZA, 2-(tert-butyl)-9-fluoro-3H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one, 7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-, 9-Fluoro-2-(2-methyl-2-propanyl)-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

Pyridone 6 (CAS 457081-03-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C18H16FN3O and a molecular weight of 309.337 g/mol. Key properties include a boiling point of 646.5±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 344.8±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 457081-03-7
Jingsj CID: J-1398792-9
Molecular Formula: C₁₈H₁₆FN₃O
Molecular Weight: 309.337 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	646.5±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	344.8±31.5 °C
Exact Mass	309.127747
PSA	61.80000
LogP	3.00
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.681
Storage Conditions	2-8℃

Activity & Biological Data

Target	JAK2:1 nM (IC50) Tyk2:1 nM (IC50) JAK3:5 nM (IC50) Murine JAK1:15 nM (IC50) CDK2:3.3 μM (IC50) cAMP-dependent kinase:7.1 μM (IC50) Csk:2.1 μM (IC50) Hck:7.7 μM (IC50) Fyn T:0.5 μM (IC50) p38:11 μM (IC50) MAPK:1.78 μM (IC50) Mek:0.16 μM (IC50) IκB Kinase 2:0.3 μM (IC50) KDR:1.4 μM (IC50) Flt-1:1.52 μM (IC50) Flt-4:0.69 μM (IC50) FGFR:1.48 μM (IC50) FGFR2:0.94 μM (IC50) Tek:24 μM (IC50) PDGFR:1.49 μM (IC50) PKC(α):1.2 μM (IC50)
Additional Information	[1]. Thompson JE, et al. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23. [2]. Nakagawa R, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.

Target

JAK2:1 nM (IC50) Tyk2:1 nM (IC50) JAK3:5 nM (IC50) Murine JAK1:15 nM (IC50) CDK2:3.3 μM (IC50) cAMP-dependent kinase:7.1 μM (IC50) Csk:2.1 μM (IC50) Hck:7.7 μM (IC50) Fyn T:0.5 μM (IC50) p38:11 μM (IC50) MAPK:1.78 μM (IC50) Mek:0.16 μM (IC50) IκB Kinase 2:0.3 μM (IC50) KDR:1.4 μM (IC50) Flt-1:1.52 μM (IC50) Flt-4:0.69 μM (IC50) FGFR:1.48 μM (IC50) FGFR2:0.94 μM (IC50) Tek:24 μM (IC50) PDGFR:1.49 μM (IC50) PKC(α):1.2 μM (IC50)

Additional Information

[1]. Thompson JE, et al. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23. [2]. Nakagawa R, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.

Frequently Asked Questions

What is the CAS number of Pyridone 6?

The CAS number of Pyridone 6 is 457081-03-7.

What are the molecular formula and molecular weight of Pyridone 6?

Pyridone 6 has molecular formula C18H16FN3O and molecular weight 309.337 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pyridone 6 (CAS 457081-03-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1398792-9 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.