2-Hydroxysaclofen

Also known as: 2-OH-Saclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid, Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-, MFCD00069282

2-Hydroxysaclofen (CAS 117354-64-0) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C9H12ClNO4S and a molecular weight of 265.71400 g/mol. Key properties include a melting point of 267-269ºC and a density of 1.551 g/cm3. It is classified under GHS with signal word Danger and hazard statements H314 — Causes severe skin burns and eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 117354-64-0
Jingsj CID: J-12271-3
Molecular Formula: C₉H₁₂ClNO₄S
Molecular Weight: 265.71400 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	267-269ºC
Density	1.551 g/cm3
Exact Mass	265.01800
PSA	109.00000
LogP	2.15520
Refractive Index	1.63

GHS Safety & Compliance

CorrosionSignal word: Danger

H314 — Causes severe skin burns and eye damage

Activity & Biological Data

Target	GABAB receptor[1]
Additional Information	[1]. Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5. [2]. Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93(1):25-30. [3]. Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546(1):143-5.

Target

GABAB receptor[1]

Additional Information

[1]. Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5. [2]. Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93(1):25-30. [3]. Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546(1):143-5.

Frequently Asked Questions

What is the CAS number of 2-Hydroxysaclofen?

The CAS number of 2-Hydroxysaclofen is 117354-64-0.

What are the molecular formula and molecular weight of 2-Hydroxysaclofen?

2-Hydroxysaclofen has molecular formula C9H12ClNO4S and molecular weight 265.71400 g/mol.

Is 2-Hydroxysaclofen hazardous?

2-Hydroxysaclofen has GHS signal word Danger and hazard statements H314 — Causes severe skin burns and eye damage.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-Hydroxysaclofen (CAS 117354-64-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12271-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.