Isofraxidin
Also known as: 7-Hydroxy-6,8-dimethoxychromen-2-one, 7-Hydroxy-6,8-dimethoxy-2H-chromen-2-one, 6,8-Dimethoxy-7-hydroxycoumarin, 6,8-Dimethoxyumbelliferone, 7-Hydroxy-6,8-dimethoxycoumarin, Phytodolor, NSC 324637, AKOS 243-93, MFCD00221757, Coumarin, 7-hydroxy-6,8-dimethoxy, Umbelliferone, 6,8-dimethoxy, iso-Fraxidin, isoferaxidin
Isofraxidin (CAS 486-21-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C11H10O5 and a molecular weight of 222.194 g/mol. Key properties include a melting point of >300 °C(lit.), a boiling point of 452.1±45.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 183.2±22.2 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.
- CAS No.
- 486-21-5
- Jingsj CID
- J-11800-3
- Molecular Formula
- C11H10O5
- Molecular Weight
- 222.194 g/mol
- Category
- Organic Compounds
- Last updated
- 11/3/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | >300 °C(lit.) |
|---|---|
| Boiling Point | 452.1±45.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 183.2±22.2 °C |
| Exact Mass | 222.052826 |
| PSA | 68.90000 |
| LogP | 1.31 |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 1.588 |
| Additional Property | slightly soluble |
Activity & Biological Data
| Target | COX-2 TLR4 MMP-7 |
|---|---|
| Additional Information | [1]. Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22. [2]. Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652. |
Frequently Asked Questions
What is the CAS number of Isofraxidin?
The CAS number of Isofraxidin is 486-21-5.
What are the molecular formula and molecular weight of Isofraxidin?
Isofraxidin has molecular formula C11H10O5 and molecular weight 222.194 g/mol.
What are the upstream and downstream products of Isofraxidin?
For Isofraxidin, Upstream Products: Calycanthoside, 3,5-dibromo-2,4-dihydroxybenzaldehyde, 2,4-Dihydroxybenzaldehyde; Downstream Products: Dimethylfraxetin.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Isofraxidin (CAS 486-21-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11800-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.