Clozapine
Also known as: Clozaril, Leponex, HF-1854, W-801, Iprox, Lepotex, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, 8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Clozapine (CAS 5786-21-0) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H19ClN4 and a molecular weight of 326.823 g/mol. Key properties include a melting point of 182-185°C, a boiling point of 489.2±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 249.6±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H341 — Suspected of causing genetic defects and H361 — Suspected of damaging fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 5786-21-0
- Jingsj CID
- J-11424-2
- Molecular Formula
- C18H19ClN4
- Molecular Weight
- 326.823 g/mol
- Category
- Organohalogen Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 182-185°C |
|---|---|
| Boiling Point | 489.2±55.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 249.6±31.5 °C |
| Exact Mass | 326.129822 |
| PSA | 30.87000 |
| LogP | 2.36 |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| Refractive Index | 1.681 |
| Additional Property | ethanol: 1 mg/mL |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H341 — Suspected of causing genetic defects
- H361 — Suspected of damaging fertility or the unborn child
Activity & Biological Data
| Target | Ki: 9.5 nM (M1), 51 nM (α2-adrenoceptor), 75 nM (D2)[1] |
|---|---|
| Additional Information | [1]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. [2]. Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. [3]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Clozapine?
The CAS number of Clozapine is 5786-21-0.
What are the molecular formula and molecular weight of Clozapine?
Clozapine has molecular formula C18H19ClN4 and molecular weight 326.823 g/mol.
Is Clozapine hazardous?
Clozapine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H341 — Suspected of causing genetic defects; H361 — Suspected of damaging fertility or the unborn child.
What are the upstream and downstream products of Clozapine?
For Clozapine, Upstream Products: 1-Methylpiperazine, 8-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, N-(2-Amino-4-chlorophenyl)anthranilic acid; Downstream Products: N-Desmethylclozapine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Clozapine (CAS 5786-21-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11424-2 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.