Melatonin

Also known as: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, N-acetyl-5-methoxytryptamine, 5-Methoxy-N-acetyltryptamine, Circadin, Melovine, MLT

Melatonin (CAS 73-31-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H16N2O2 and a molecular weight of 232.278 g/mol. Key properties include a melting point of 116.5-118 °C(lit.), a boiling point of 459.8±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 231.9±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 73-31-4
Jingsj CID: J-1106343-7
Molecular Formula: C₁₃H₁₆N₂O₂
Molecular Weight: 232.278 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	116.5-118 °C(lit.)
Boiling Point	459.8±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	231.9±31.5 °C
Exact Mass	232.121185
PSA	54.12000
LogP	1.94
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.580

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

Target

Human Endogenous Metabolite

Additional Information

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Melatonin?

The CAS number of Melatonin is 73-31-4.

What are the molecular formula and molecular weight of Melatonin?

Melatonin has molecular formula C13H16N2O2 and molecular weight 232.278 g/mol.

Is Melatonin hazardous?

Melatonin has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of Melatonin?

For Melatonin, Upstream Products: 5-Methoxytryptamine, N-Acetylserotonin, Dimethyl sulfate; Downstream Products: Serotonin, 2',3'-O-Isopropylideneuridine, 5-Methoxytryptamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Melatonin (CAS 73-31-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1106343-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.