Naltrindole hydrochloride

Also known as: NTI hydrochloride, 17-(Cyclopropylmethyl)-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride, MFCD00069313, Naltrindole (hydrochloride)

Naltrindole hydrochloride (CAS 111469-81-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C26H27ClN2O3 and a molecular weight of 450.95700 g/mol. Key properties include a boiling point of 664.2ºC at 760mmHg and a flash point of 355.5ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 111469-81-9
Jingsj CID: J-1083577-5
Molecular Formula: C₂₆H₂₇ClN₂O₃
Molecular Weight: 450.95700 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	664.2ºC at 760mmHg
Flash Point	355.5ºC
Exact Mass	450.17100
PSA	68.72000
LogP	4.31250
Vapor Pressure	1.51E-18mmHg at 25°C

Activity & Biological Data

Target	Ki: 0.02 nM (δ opioid), 64 nM (μ opioid), 66 nM (κ opioid)[1]
Additional Information	[1]. Raynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. [2]. Mundra JJ, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther. 2012 Aug;342(2):273-87. [3]. Chen YL, et al. Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells. [4]. Portoghese PS, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol. 1988 Jan 27;146(1):185-6. [5]. Fernández B, et al. Postnatal naltrindole treatments induce behavioural modifications in preweanling rats. Neurosci Lett. 2000 Mar 31;283(1):73-6.

Target

Ki: 0.02 nM (δ opioid), 64 nM (μ opioid), 66 nM (κ opioid)[1]

Additional Information

[1]. Raynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. [2]. Mundra JJ, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther. 2012 Aug;342(2):273-87. [3]. Chen YL, et al. Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells. [4]. Portoghese PS, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol. 1988 Jan 27;146(1):185-6. [5]. Fernández B, et al. Postnatal naltrindole treatments induce behavioural modifications in preweanling rats. Neurosci Lett. 2000 Mar 31;283(1):73-6.

Frequently Asked Questions

What is the CAS number of Naltrindole hydrochloride?

The CAS number of Naltrindole hydrochloride is 111469-81-9.

What are the molecular formula and molecular weight of Naltrindole hydrochloride?

Naltrindole hydrochloride has molecular formula C26H27ClN2O3 and molecular weight 450.95700 g/mol.

What are the upstream and downstream products of Naltrindole hydrochloride?

For Naltrindole hydrochloride, Upstream Products: Naltrexone hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Naltrindole hydrochloride (CAS 111469-81-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1083577-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.